Lupus

Lupus is an autoimmune inflammatory condition in which your body’s defence system attacks parts of your own body. Lupus may involve only the skin (discoid lupus) or many other parts of the body (systemic lupus erythematosus or SLE) such as the heart, lungs, blood and joints. SLE is seen more often in young adult population and is more likely to occur in women than men.

Causes of Lupus

SLE occurs when the body identifies its own body tissue as non-self by mistake and starts making autoantibodies against it. Inappropriate immune response leads to inflammation and thus causes damage to these body tissues.

Symptoms of Lupus

SLE may cause general symptoms such as fever, fatigue, mouth sores, hair loss, stomach pain, nausea and vomiting, abnormal heart rhythm, chest pain with deep breaths, headaches, seizures, difficulty breathing, and haemoptysis. SLE also causes a characteristic butterfly shaped rash on the nose and cheeks called malar rash with exposure to the sun. A raised oval discoid rash is also seen in some cases.

Diagnosis of Lupus

For diagnosis of SLE various tests are done including blood tests, urine analysis, chest X-ray and kidney biopsy. Blood tests are most important for the diagnosis and include complete blood cell count and antibody tests such as antinuclear antibody, anti-double strand DNA and anti-phospholipid.

Treatment of Lupus

There is no cure for SLE and treatment is aimed at managing the symptoms. Treatment is provided based on the type and severity of the symptoms and includes non-steroidal anti-inflammatory drugs (NSAIDS), anti-malarial drugs, corticosteroid and immunosuppressants. A drug belonging to a new class of drugs called biologics has been recently approved for treatment of mild to moderate SLE.

SLE symptoms may go away completely or flare up suddenly. Thus, frequent and regular heath check-ups are required to manage the disease.


Rheumatology Specialists